Diabetes induces significant alterations in glial cells, contributing to neurodegenerative changes in the CNS and PNS. This review examines the roles of astrocytes, microglia, and Schwann cells in diabetic neuropathy and retinopathy.
The authors highlight the dual role of glial cells in maintaining neural integrity and mediating inflammatory responses. In diabetic conditions, dysregulated glial activity exacerbates neuronal damage and cognitive decline.
Targeting glial cell dysfunction through anti-inflammatory or neuroprotective therapies offers potential avenues for mitigating diabetes-related neurodegeneration.
