Seeking solutions to potentiate nervous system regeneration.
Understanding the mechanisms behind myelin formation, maintenance, and regeneration in both the central and peripheral nervous systems
Welcome to Myelin Alicante labs, where our team is dedicated to unraveling the complexities of myelin and its role in neurological disorders.
Our research focuses on understanding the mechanisms behind myelin formation, maintenance, and regeneration in both the central and peripheral nervous systems.
We study Schwann cells and oligodendrocyte lineage cells to gain insights into the production and upkeep of myelin in health and disease.
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Our overarching aim is to better understand the underlying causes of peripheral neuropathies and demyelinating disorders.
These conditions can severely impact the nervous system, leading to symptoms such as numbness, pain, coordination difficulties, muscle weakness, and disruptions in bodily functions like blood pressure regulation, digestion, and bladder control.
By deepening our understanding of the pathophysiological mechanisms that initiate neuropathies, we strive to pave the way for effective treatments.
One of our primary objectives is to comprehend the mechanisms that impede regeneration in ageing peripheral nerves and the central nervous system.
With the aging population becoming a pressing concern in industrialized nations, it is crucial to identify the defective processes hindering Schwann cell and oligodendrocyte responses during the repair process.
By addressing the decline in regenerative capacity associated with age, we aim to mitigate the consequences of age-linked neurological disorders on the peripheral and central nervous systems.
We also investigate the intricate interplay between inflammation and glial cells to comprehend how it influences myelin maintenance and repair in health and disease.
Although inflammation and myelin alterations have been extensively studied in various neurological disorders, the bidirectional communication between inflammation, Schwann cells and oligodendrocyte lineage cells remains poorly understood.
We aim to elucidate the cellular and molecular mechanisms through which acute and chronic inflammation affect the Schwann cell and oligodendrocyte lineage cell response damage.
Using in vitro and in vivo experimental models, transgenic and pharmacological manipulation, as well as «omics» approaches, we investigate intrinsic, local, and systemic factors that influence the response of Schwann cells, oligodendrocytes, and OPCs in an inflammatory context.
Our ultimate goal is to overcome barriers to myelin regeneration and to contribute to the development of effective and innovative therapies that benefit patients with neurological disorders associated with myelin abnormalities.
We invite you to explore our website and learn more about our ongoing research, publications, and the passionate individuals who comprise our team. Together, we are dedicated to advancing myelin research and making significant contributions to the understanding and treatment of neurological diseases from Alicante, Spain.
Research Lines
Welcome to Myelin Alicante Labs, a vibrant hub of research excellence nestled between ISABIAL and the Institute of Neurosciences CSIC-UMH, where we specialize in the study of glia, myelin, and remyelination in both the peripheral nervous system (PNS) and the central nervous system (CNS). Our research focuses on unraveling the intricacies of these vital components and their roles in maintaining neural health and function.
At Myelin Alicante Labs, our team of dedicated researchers and principal investigators are at the forefront of investigating these complex processes. Through state-of-the-art methodologies and cutting-edge technologies, we delve into the intricate interactions between glia, myelin, and the surrounding neuronal environment.
Our team is composed of three principal investigators, dedicated to pushing the boundaries of scientific discovery. Explore our website to learn more about our ongoing research projects, publications, and the remarkable contributions our team is making in the field of glia. Join us on this exciting journey as we strive to unlock the mysteries of the nervous system and pave the way for improved therapies and treatments.
