CNS PNS PNS - CNS

CNS

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: CNS

Publication Category: CNS

Navigating the transition to Principal Investigator

Journal:

Wiley

Publication Date:

16/09/2024

Type:

comment

Open Access:

https://doi.org/10.1111/imcb.12821

Category:

CNS

Tags:

Academia

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

Journal:

Molecular Neurodegeneration

Publication Date:

05/04/2024

Type:

journal-article

Open Access:

https://doi.org/10.1186/s13024-024-00724-w

Category:

CNS

Tags:

Ageing, Inflammation, Neurodegeneration, Regulatory T cells, Retina

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

Journal:

Nature Communications

Publication Date:

11/03/2024

Type:

journal-article

Open Access:

https://doi.org/10.1038/s41467-024-45742-w

Category:

CNS

Tags:

Ageing, Multiple Sclerosis, Neuroimmunology, Regulatory T cells

A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis

Journal:

eLife

Publication Date:

09/01/2024

Type:

journal-article

Open Access:

https://doi.org/10.7554/elife.79169

Category:

CNS

Tags:

Axonal Pathology, MRI, Multiple Sclerosis, Neuroscience

Brain-specific regulatory T cell expansion limits cognitive decline

Brain-specific regulatory T cell expansion limits cognitive decline

Journal:

Trends in Molecular Medicine

Publication Date:

20/05/2023

Type:

comment

Open Access:

https://doi.org/10.1016/j.molmed.2023.05.001

Category:

CNS

Tags:

Ageing, Glial Cells, Regulatory T cells

Novel therapeutic approaches to target neurodegeneration

Novel therapeutic approaches to target neurodegeneration

Journal:

British Journal of Pharmacology

Publication Date:

26/04/2023

Type:

review

Open Access:

https://doi.org/10.1111/bph.16078

Category:

CNS

Tags:

Ageing, Inflammation, Neurodegeneration, Therapeutic Approaches

Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter

Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter

Journal:

BMC Neuroscience

Publication Date:

17/03/2023

Type:

journal-article

Open Access:

https://doi.org/10.1186/s12868-023-00788-2

Category:

CNS

Tags:

Duchenne muscular dystrophy, MRI

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Journal:

bioRxiv

Publication Date:

25/01/2023

Type:

preprint

Open Access:

https://doi.org/10.1101/2023.01.25.525562

Category:

CNS

Tags:

Ageing, Oligodendrocytes, Regulatory T cells, Remyelination

Autoantibodies and microglia: boon or bane?

Autoantibodies and microglia: boon or bane?

Journal:

Brain

Publication Date:

04/09/2021

Type:

comment

Open Access:

https://doi.org/10.1093/brain/awab269

Category:

CNS

Tags:

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis

Journal:

Journal of Neurology, Neurosurgery and Psychiatry

Publication Date:

12/11/2020

Type:

journal-article

Open Access:

https://doi.org/10.1136/jnnp-2020-324286

Category:

CNS

Tags:

Multiple Sclerosis, Remyelination, Therapeutic Approaches

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Journal:

Frontiers in Aging Neuroscience

Publication Date:

23/09/2020

Type:

review

Open Access:

https://doi.org/10.3389/fnagi.2020.572090

Category:

CNS

Tags:

Ageing, Glial Cells, Immune cells, Neurodegeneration

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Journal:

Proceedings of the National Academy of Sciences

Publication Date:

28/07/2020

Type:

journal-article

Open Access:

https://doi.org/10.1073/pnas.1922089117

Category:

CNS

Tags:

Oligodendrocytes, Regulatory T cells, Remyelination

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Journal:

Cell

Publication Date:

20/07/2020

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.cell.2020.06.026

Category:

CNS

Tags:

Development, Immune cells, Microglia, Regulatory T cells

Changes in the oligodendrocyte progenitor cell proteome with ageing

Changes in the oligodendrocyte progenitor cell proteome with ageing

Journal:

Molecular & Cellular Proteomics

Publication Date:

20/05/2020

Type:

journal-article

Open Access:

https://doi.org/10.1074/mcp.ra120.002102

Category:

CNS

Tags:

Ageing, Myelin, Oligodendrocytes, OPC´s

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Journal:

Glia

Publication Date:

28/02/2020

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23789

Category:

CNS

Tags:

Ageing, Myelination, Oligodendrocytes, Remyelination

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Journal:

Frontiers in immunology

Publication Date:

12/09/2019

Type:

review

Open Access:

https://doi.org/10.3389/fimmu.2019.02171

Category:

CNS

Tags:

Immune cells, Multiple Sclerosis, Neurodegeneration, Therapeutic Approaches

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Journal:

Glia

Publication Date:

03/04/2019

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23624

Category:

CNS

Tags:

Ageing, Mesenchymal Stem Cells, Oligodendrocytes, Remyelination

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Journal:

Frontiers in Cellular Neuroscience

Publication Date:

27/03/2019

Type:

journal-article

Open Access:

https://doi.org/10.3389/fncel.2019.00085

Category:

CNS

Tags:

Multiple Sclerosis, Oligodendrocytes, Pericytes, Remyelination

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells

Journal:

Journal of Cell Biology

Publication Date:

02/04/2018

Type:

journal-article

Open Access:

https://doi.org/10.1083/jcb.201611150

Category:

CNS

Tags:

Schwann Cells

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Journal:

Cell Reports

Publication Date:

01/08/2017

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.celrep.2017.08.007

Category:

CNS

Tags:

Multiple Sclerosis, Oligodendrocytes, Pericytes

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Journal:

Journal of Cell Biology

Publication Date:

07/12/2015

Type:

journal-article

Open Access:

https://doi.org/10.1083/jcb.201505119

Category:

CNS

Tags:

Macrophages, Nuclear Receptor, Oligodendrocytes

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Journal:

Brain

Publication Date:

13/10/2015

Type:

journal-article

Open Access:

https://doi.org/10.1093/brain/awv289

Category:

CNS

Tags:

Multiple Sclerosis, Nuclear Receptor, Oligodendrocytes, Remyelination

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

Journal:

JCI

Publication Date:

08/05/2013

Type:

journal-article

Open Access:

https://doi.org/10.1172/JCI65401

Category:

CNS

Tags:

Alzheimer’s disease, Endocytosis, Synaptic Plasticity

Masking of transmembrane-based retention signals controls ER export of gamma-secretase.

Masking of transmembrane-based retention signals controls ER export of gamma-secretase.

Journal:

Traffic

Publication Date:

04/01/2010

Type:

journal-article

Open Access:

https://doi.org/10.1111/j.1600-0854.2009.01014.x

Category:

CNS

Tags:

Alzheimer’s disease, Endocytosis, Gamma Secretase

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

Journal:

PNAS

Publication Date:

18/11/2009

Type:

journal-article

Open Access:

https://doi.org/10.1073/pnas.1905787116

Category:

CNS

Tags:

Glial Cells, Immune cells, Microbiome, Remyelination

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

Journal:

Journal of Cell Science

Publication Date:

01/03/2006

Type:

journal-article

Open Access:

https://doi.org/10.1242/jcs.02799

Category:

CNS

Tags:

Oligodendrocytes

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

+34 965 913 949 hello@myelinalicante.com myelinalicante
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