This commentary discusses the dual roles of autoantibodies in modulating microglial activity. While autoantibodies can promote immune surveillance and tissue repair, they also risk exacerbating neuroinflammation and contributing to autoimmune pathologies.
The article emphasizes the context-dependent effects of these interactions, particularly in diseases like multiple sclerosis and Alzheimer’s disease.
Understanding the balance between protective and harmful microglial activation could guide the development of targeted immunotherapies for neuroinflammatory disorders.
