CNS PNS PNS - CNS

Ageing

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: Ageing

publication tag: Ageing

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

Journal:

Molecular Neurodegeneration

Publication Date:

05/04/2024

Type:

journal-article

Open Access:

https://doi.org/10.1186/s13024-024-00724-w

Category:

CNS

Tags:

Ageing, Inflammation, Neurodegeneration, Regulatory T cells, Retina

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

Journal:

Nature Communications

Publication Date:

11/03/2024

Type:

journal-article

Open Access:

https://doi.org/10.1038/s41467-024-45742-w

Category:

CNS

Tags:

Ageing, Multiple Sclerosis, Neuroimmunology, Regulatory T cells

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Journal:

EMBO Molecular Medicine

Publication Date:

07/12/2023

Type:

journal-article

Open Access:

https://doi.org/10.15252/emmm.202317907

Category:

PNS

Tags:

Ageing, Chronic denervation, Nerve regeneration, Schwann Cells, Senescence

Brain-specific regulatory T cell expansion limits cognitive decline

Brain-specific regulatory T cell expansion limits cognitive decline

Journal:

Trends in Molecular Medicine

Publication Date:

20/05/2023

Type:

comment

Open Access:

https://doi.org/10.1016/j.molmed.2023.05.001

Category:

CNS

Tags:

Ageing, Glial Cells, Regulatory T cells

Novel therapeutic approaches to target neurodegeneration

Novel therapeutic approaches to target neurodegeneration

Journal:

British Journal of Pharmacology

Publication Date:

26/04/2023

Type:

review

Open Access:

https://doi.org/10.1111/bph.16078

Category:

CNS

Tags:

Ageing, Inflammation, Neurodegeneration, Therapeutic Approaches

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Journal:

bioRxiv

Publication Date:

25/01/2023

Type:

preprint

Open Access:

https://doi.org/10.1101/2023.01.25.525562

Category:

CNS

Tags:

Ageing, Oligodendrocytes, Regulatory T cells, Remyelination

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Journal:

bioRxiv

Publication Date:

08/12/2022

Type:

preprint

Open Access:

https://doi.org/10.1101/2022.12.07.519441

Category:

PNS

Tags:

Ageing, Nerve injury, Schwann Cells, Senescence

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Journal:

eLife

Publication Date:

21/01/2021

Type:

journal-article

Open Access:

https://doi.org/10.7554/elife.62232

Category:

PNS

Tags:

Ageing, Nerve injury, Regeneration, Schwann Cells

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Journal:

Frontiers in Aging Neuroscience

Publication Date:

23/09/2020

Type:

review

Open Access:

https://doi.org/10.3389/fnagi.2020.572090

Category:

CNS

Tags:

Ageing, Glial Cells, Immune cells, Neurodegeneration

Changes in the oligodendrocyte progenitor cell proteome with ageing

Changes in the oligodendrocyte progenitor cell proteome with ageing

Journal:

Molecular & Cellular Proteomics

Publication Date:

20/05/2020

Type:

journal-article

Open Access:

https://doi.org/10.1074/mcp.ra120.002102

Category:

CNS

Tags:

Ageing, Myelin, Oligodendrocytes, OPC´s

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Journal:

Glia

Publication Date:

28/02/2020

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23789

Category:

CNS

Tags:

Ageing, Myelination, Oligodendrocytes, Remyelination

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Journal:

Glia

Publication Date:

03/04/2019

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23624

Category:

CNS

Tags:

Ageing, Mesenchymal Stem Cells, Oligodendrocytes, Remyelination

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

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