CNS PNS PNS - CNS

Oligodendrocytes

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: Oligodendrocytes

publication tag: Oligodendrocytes

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

Journal:

Frontiers in Cellular Neuroscience

Publication Date:

19/05/2023

Type:

journal-article

Open Access:

https://doi.org/10.3389/fncel.2023.1158388

Category:

PNS - CNS

Tags:

Development, Myelination, Oligodendrocytes, Schwann Cells

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Journal:

bioRxiv

Publication Date:

25/01/2023

Type:

preprint

Open Access:

https://doi.org/10.1101/2023.01.25.525562

Category:

CNS

Tags:

Ageing, Oligodendrocytes, Regulatory T cells, Remyelination

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Journal:

Proceedings of the National Academy of Sciences

Publication Date:

28/07/2020

Type:

journal-article

Open Access:

https://doi.org/10.1073/pnas.1922089117

Category:

CNS

Tags:

Oligodendrocytes, Regulatory T cells, Remyelination

Changes in the oligodendrocyte progenitor cell proteome with ageing

Changes in the oligodendrocyte progenitor cell proteome with ageing

Journal:

Molecular & Cellular Proteomics

Publication Date:

20/05/2020

Type:

journal-article

Open Access:

https://doi.org/10.1074/mcp.ra120.002102

Category:

CNS

Tags:

Ageing, Myelin, Oligodendrocytes, OPC´s

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Journal:

Glia

Publication Date:

28/02/2020

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23789

Category:

CNS

Tags:

Ageing, Myelination, Oligodendrocytes, Remyelination

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Journal:

Glia

Publication Date:

03/04/2019

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23624

Category:

CNS

Tags:

Ageing, Mesenchymal Stem Cells, Oligodendrocytes, Remyelination

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Journal:

Frontiers in Cellular Neuroscience

Publication Date:

27/03/2019

Type:

journal-article

Open Access:

https://doi.org/10.3389/fncel.2019.00085

Category:

CNS

Tags:

Multiple Sclerosis, Oligodendrocytes, Pericytes, Remyelination

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Journal:

Cell Reports

Publication Date:

01/08/2017

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.celrep.2017.08.007

Category:

CNS

Tags:

Multiple Sclerosis, Oligodendrocytes, Pericytes

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Journal:

Journal of Cell Biology

Publication Date:

07/12/2015

Type:

journal-article

Open Access:

https://doi.org/10.1083/jcb.201505119

Category:

CNS

Tags:

Macrophages, Nuclear Receptor, Oligodendrocytes

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Journal:

Brain

Publication Date:

13/10/2015

Type:

journal-article

Open Access:

https://doi.org/10.1093/brain/awv289

Category:

CNS

Tags:

Multiple Sclerosis, Nuclear Receptor, Oligodendrocytes, Remyelination

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

Journal:

Journal of Cell Science

Publication Date:

01/03/2006

Type:

journal-article

Open Access:

https://doi.org/10.1242/jcs.02799

Category:

CNS

Tags:

Oligodendrocytes

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

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