CNS PNS PNS - CNS

Nerve injury

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: Nerve injury

publication tag: Nerve injury

Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies

Journal:

Cold Spring Harbor Perspectives in Biology

Publication Date:

03/06/2024

Type:

review

Open Access:

https://doi.org/10.1101/cshperspect.a041363

Category:

PNS

Tags:

Glial Cells, Inflammation, Myelin, Myelination, Nerve injury, Regeneration, Remyelination, Schwann Cells

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Journal:

CellPress

Publication Date:

05/12/2023

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.cmet.2023.10.017

Category:

PNS

Tags:

Adipocytes, Metabolism, Myelin, Nerve injury, Nerve repair, Regeneration, Remyelination, Schwann Cells

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Journal:

bioRxiv

Publication Date:

08/12/2022

Type:

preprint

Open Access:

https://doi.org/10.1101/2022.12.07.519441

Category:

PNS

Tags:

Ageing, Nerve injury, Schwann Cells, Senescence

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

Journal:

eLife

Publication Date:

25/01/2022

Type:

journal-article

Open Access:

https://doi.org/10.7554/eLife.72917

Category:

PNS

Tags:

Epigenetics, Myelination, Nerve injury, Schwann Cells

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Journal:

eLife

Publication Date:

21/01/2021

Type:

journal-article

Open Access:

https://doi.org/10.7554/elife.62232

Category:

PNS

Tags:

Ageing, Nerve injury, Regeneration, Schwann Cells

Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

Journal:

Journal of Neuroscience

Publication Date:

13/12/2017

Type:

journal-article

Open Access:

https://doi.org/10.1523/JNEUROSCI.0986-17.2017

Category:

PNS

Tags:

Myelination, Nerve injury, Regeneration, Schwann Cells

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

Journal:

Cell Reports

Publication Date:

12/09/2017

Type:

comment

Open Access:

https://doi.org/10.1016/j.celrep.2017.08.064

Category:

PNS

Tags:

Myelination, Nerve injury, Regeneration, Schwann Cells

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

+34 965 913 949 hello@myelinalicante.com myelinalicante
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