CNS PNS PNS - CNS

PNS

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: PNS

Publication Category: PNS

Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies

Journal:

Cold Spring Harbor Perspectives in Biology

Publication Date:

03/06/2024

Type:

review

Open Access:

https://doi.org/10.1101/cshperspect.a041363

Category:

PNS

Tags:

Glial Cells, Inflammation, Myelin, Myelination, Nerve injury, Regeneration, Remyelination, Schwann Cells

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Journal:

EMBO Molecular Medicine

Publication Date:

07/12/2023

Type:

journal-article

Open Access:

https://doi.org/10.15252/emmm.202317907

Category:

PNS

Tags:

Ageing, Chronic denervation, Nerve regeneration, Schwann Cells, Senescence

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Journal:

CellPress

Publication Date:

05/12/2023

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.cmet.2023.10.017

Category:

PNS

Tags:

Adipocytes, Metabolism, Myelin, Nerve injury, Nerve repair, Regeneration, Remyelination, Schwann Cells

Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells

Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells

Journal:

Immunology & Cell Biology

Publication Date:

03/01/2023

Type:

journal-article

Open Access:

https://doi.org/10.1111/imcb.12610

Category:

PNS

Tags:

Immune cells, Neurodegeneration, Neuroimmunology

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Journal:

bioRxiv

Publication Date:

08/12/2022

Type:

preprint

Open Access:

https://doi.org/10.1101/2022.12.07.519441

Category:

PNS

Tags:

Ageing, Nerve injury, Schwann Cells, Senescence

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

Journal:

PLOS Genetics

Publication Date:

06/06/2022

Type:

journal-article

Open Access:

https://doi.org/10.1371/journal.pgen.1010224

Category:

PNS

Tags:

An Experimental Model of Neuro-Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells

An Experimental Model of Neuro-Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells

Journal:

International Journal of Molecular Sciences

Publication Date:

10/03/2022

Type:

journal-article

Open Access:

https://doi.org/10.3390/ijms23062997

Category:

PNS

Tags:

Cornea

Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets

Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets

Journal:

International Journal of Molecular Sciences

Publication Date:

10/03/2022

Type:

journal-article

Open Access:

https://doi.org/10.3390/ijms23062996

Category:

PNS

Tags:

Epigenetics, Myelination, Regeneration, Schwann Cells

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

Journal:

eLife

Publication Date:

25/01/2022

Type:

journal-article

Open Access:

https://doi.org/10.7554/eLife.72917

Category:

PNS

Tags:

Epigenetics, Myelination, Nerve injury, Schwann Cells

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Journal:

eLife

Publication Date:

21/01/2021

Type:

journal-article

Open Access:

https://doi.org/10.7554/elife.62232

Category:

PNS

Tags:

Ageing, Nerve injury, Regeneration, Schwann Cells

Novel EGR2 variant that associates with Charcot-Marie-Tooth disease when combined with lipopolysaccharide-induced TNF-α factor T49M polymorphism

Novel EGR2 variant that associates with Charcot-Marie-Tooth disease when combined with lipopolysaccharide-induced TNF-α factor T49M polymorphism

Journal:

Neurology Genetics

Publication Date:

03/03/2020

Type:

journal-article

Open Access:

https://doi.org/10.1212/NXG.0000000000000407

Category:

PNS

Tags:

Class IIa HDACs in myelination

Class IIa HDACs in myelination

Journal:

Aging (Albany NY)

Publication Date:

05/05/2018

Type:

editorial

Open Access:

https://www.aging-us.com/article/101443

Category:

PNS

Tags:

Epigenetics, Schwann Cells

Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

Journal:

Journal of Neuroscience

Publication Date:

13/12/2017

Type:

journal-article

Open Access:

https://doi.org/10.1523/JNEUROSCI.0986-17.2017

Category:

PNS

Tags:

Myelination, Nerve injury, Regeneration, Schwann Cells

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

Journal:

Cell Reports

Publication Date:

12/09/2017

Type:

comment

Open Access:

https://doi.org/10.1016/j.celrep.2017.08.064

Category:

PNS

Tags:

Myelination, Nerve injury, Regeneration, Schwann Cells

STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration

STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration

Journal:

Journal of Neuroscience

Publication Date:

19/04/2017

Type:

journal-article

Open Access:

https://doi.org/

Category:

PNS

Tags:

Schwann Cells

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

Journal:

Journal of Cell Biology

Publication Date:

06/07/2015

Type:

journal-article

Open Access:

https://doi.org/

Category:

PNS

Tags:

Schwann Cells

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

Journal:

Brain

Publication Date:

31/07/2013

Type:

journal-article

Open Access:

https://doi.org/10.1093/brain/awt130

Category:

PNS

Tags:

Schwann Cells, Senescence

L1CAM Binds ErbB Receptors through Ig-Like Domains Coupling Cell Adhesion and Neuregulin Signalling

L1CAM Binds ErbB Receptors through Ig-Like Domains Coupling Cell Adhesion and Neuregulin Signalling

Journal:

Plos ONE

Publication Date:

16/07/2012

Type:

journal-article

Open Access:

https://doi.org/10.1371/journal.pone.0040674

Category:

PNS

Tags:

Sustained Axon-Glial Signaling Induces Schwann Cell Hyperproliferation, Remak Bundle Myelination, and Tumorigenesis

Sustained Axon-Glial Signaling Induces Schwann Cell Hyperproliferation, Remak Bundle Myelination, and Tumorigenesis

Journal:

Journal of Neuroscience

Publication Date:

09/09/2009

Type:

journal-article

Open Access:

https://doi.org/10.1523/JNEUROSCI.1753-09.2009

Category:

PNS

Tags:

Schwann Cells

Lipid Raft Segregation Modulates TRPM8 Channel Activity

Lipid Raft Segregation Modulates TRPM8 Channel Activity

Journal:

Journal of Biological Chemistry

Publication Date:

30/04/2009

Type:

journal-article

Open Access:

https://doi.org/10.1074/jbc.M807228200

Category:

PNS

Tags:

Transcriptional control of cholesterol biosynthesis in schwann cells by axonal neuregulin 1

Transcriptional control of cholesterol biosynthesis in schwann cells by axonal neuregulin 1

Journal:

Journal of Biological Chemestry

Publication Date:

28/07/2007

Type:

journal-article

Open Access:

https://doi.org/10.1074/jbc.M701878200

Category:

PNS

Tags:

Schwann Cells

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

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