This review examines histone deacetylases (HDACs) in Schwann cells and their roles in nerve regeneration and aging. HDACs regulate Schwann cell phenotypic transitions, which are essential for nerve repair.
Aging disrupts HDAC-mediated pathways, impairing Schwann cell plasticity and reducing regeneration efficiency. Therapeutic targeting of HDACs may rejuvenate Schwann cell function, improving outcomes for age-related nerve injuries.
These findings position HDAC modulation as a promising strategy for enhancing peripheral nerve repair and combating age-related deficits.
