CNS PNS PNS - CNS

Remyelination

In our laboratory, we investigate the regeneration and repair of nervous tissue through innovative approaches that integrate advanced cellular biology, neuroimmunology, and emerging therapies. We employ state-of-the-art techniques, including electron and fluorescence microscopy, to further our understanding of neurodegenerative diseases, inflammation, and tissue regeneration. Our publications reflect our commitment to pioneering research, utilising cutting-edge technologies and scientific methodologies.

Alerie Guzman de la Fuente
Jose Antonio Gomez Sanchez
Hugo Cabedo Martí

Academia Adipocytes Ageing Alzheimer’s disease Amyotrophic Lateral Sclerosis Astrocytes Axonal Pathology Chronic denervation Cognitive Decline Cornea Development Diabetes Diabetic Neuropathy Diabetic Retinopathy Duchenne muscular dystrophy Endocytosis Epigenetics Gamma Secretase Glial Cells HDAC11 Immune cells Inflammation Jun Transcription Factor Macrophages Mesenchymal Stem Cells Metabolism Microbiome Microglia Motor Neuron MRI Muller Multiple Sclerosis Muscle atrophy Myelin Myelination Nerve injury Nerve regeneration Nerve repair Neurodegeneration Neuroimmunology Neuroscience Nuclear Receptor Oligodendrocytes OPC´s Pericytes Regeneration Regulatory T cells Remyelination Retina Sarcopenia Schwann Cells Senescence Sod1g93a Mutant Synaptic Plasticity Therapeutic Approaches

Check the latest publications from Myelin Labs about: Remyelination

publication tag: Remyelination

Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies

Journal:

Cold Spring Harbor Perspectives in Biology

Publication Date:

03/06/2024

Type:

review

Open Access:

https://doi.org/10.1101/cshperspect.a041363

Category:

PNS

Tags:

Glial Cells, Inflammation, Myelin, Myelination, Nerve injury, Regeneration, Remyelination, Schwann Cells

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Journal:

CellPress

Publication Date:

05/12/2023

Type:

journal-article

Open Access:

https://doi.org/10.1016/j.cmet.2023.10.017

Category:

PNS

Tags:

Adipocytes, Metabolism, Myelin, Nerve injury, Nerve repair, Regeneration, Remyelination, Schwann Cells

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

Journal:

bioRxiv

Publication Date:

25/01/2023

Type:

preprint

Open Access:

https://doi.org/10.1101/2023.01.25.525562

Category:

CNS

Tags:

Ageing, Oligodendrocytes, Regulatory T cells, Remyelination

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis

Journal:

Journal of Neurology, Neurosurgery and Psychiatry

Publication Date:

12/11/2020

Type:

journal-article

Open Access:

https://doi.org/10.1136/jnnp-2020-324286

Category:

CNS

Tags:

Multiple Sclerosis, Remyelination, Therapeutic Approaches

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

Journal:

Proceedings of the National Academy of Sciences

Publication Date:

28/07/2020

Type:

journal-article

Open Access:

https://doi.org/10.1073/pnas.1922089117

Category:

CNS

Tags:

Oligodendrocytes, Regulatory T cells, Remyelination

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Journal:

Glia

Publication Date:

28/02/2020

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23789

Category:

CNS

Tags:

Ageing, Myelination, Oligodendrocytes, Remyelination

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Journal:

Glia

Publication Date:

03/04/2019

Type:

journal-article

Open Access:

https://doi.org/10.1002/glia.23624

Category:

CNS

Tags:

Ageing, Mesenchymal Stem Cells, Oligodendrocytes, Remyelination

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

Journal:

Frontiers in Cellular Neuroscience

Publication Date:

27/03/2019

Type:

journal-article

Open Access:

https://doi.org/10.3389/fncel.2019.00085

Category:

CNS

Tags:

Multiple Sclerosis, Oligodendrocytes, Pericytes, Remyelination

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Journal:

Brain

Publication Date:

13/10/2015

Type:

journal-article

Open Access:

https://doi.org/10.1093/brain/awv289

Category:

CNS

Tags:

Multiple Sclerosis, Nuclear Receptor, Oligodendrocytes, Remyelination

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

Journal:

PNAS

Publication Date:

18/11/2009

Type:

journal-article

Open Access:

https://doi.org/10.1073/pnas.1905787116

Category:

CNS

Tags:

Glial Cells, Immune cells, Microbiome, Remyelination

Instituto de Investigación Sanitaria y Biomédica de Alicante

(ISABIAL)

Myelin Alicante Labs
Avda Pintor Baeza, 12
Hospital General Universitario Dr Balmis
Planta 6ª Centro de Diagnóstico
03010 Alicante (Spain)

Instituto de Neurociencias

(UMH-CSIC)

Myelin Alicante Labs
Avd. Ramón y Cajal, s/n  
Campus UMH de San Juan.
03550 San Juan de Alicante Alicante (Spain)

+34 965 913 949 hello@myelinalicante.com myelinalicante
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