This study explores the role of SARM1 in myelinating glia and concludes that it is non-essential for myelination in both the peripheral (PNS) and central nervous systems (CNS) in zebrafish and mice.
While SARM1 is known for its role in axonal degeneration, its absence does not disrupt the formation or maintenance of myelin, suggesting its functions are independent of myelination pathways.
These findings refine the understanding of SARM1’s role in neural biology and suggest potential specificity in its contributions to axonal health and pathology.
