This review examines the dual roles of the adaptive immune system in aging and neurodegenerative diseases. While adaptive immunity can support tissue repair and neuroprotection, it also contributes to chronic inflammation and neuronal damage.
The authors propose that age-associated dysregulation of the immune system exacerbates neurodegenerative processes. Strategies to balance its protective and detrimental effects are critical for therapeutic success.
These insights highlight the complexity of immune interactions in the aging brain, paving the way for immunomodulatory treatments targeting neurodegenerative diseases.
