Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Journal:

Frontiers in immunology

Publication:

12/09/2019

Type:

review

Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

This review highlights the dual roles of T cells in CNS disorders, focusing on their protective and regenerative capabilities. While T cells can exacerbate inflammation, they also promote neuroprotection and tissue repair under controlled conditions.

The article explores mechanisms through which T cells contribute to remyelination and neuronal survival, emphasizing their interactions with other immune and glial cells. These insights offer potential for immunomodulatory therapies in neurodegenerative diseases.

Harnessing T cell-mediated repair mechanisms could advance treatments for conditions like multiple sclerosis, where inflammation and regeneration are tightly intertwined.